Network toxicology and ML reveal DOTP's role in SLE pathogenesis

GO and KEGG analyses link them to inflammatory cytokine production and immune activation. Six key targets—NFKB1, TLR4, CASP9, CDK5, DNMT1, PRKCD—are prioritized via PPI and ML. Molecular docking predicts favorable binding between DOTP and these targets. CIBERSORT and ROC analyses support immune cell infiltration and cohort discrimination.

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